1196800-40-4
中文名稱(chēng)
AMADACYCLINE METHANESULFONATE
英文名稱(chēng)
PTK0796 Methanesulfonate
CAS
1196800-40-4
分子式
C29H40N4O7.x(CH4O3S)
分子量
652.756
MOL 文件
1196800-40-4.mol
1196800-40-4 結(jié)構(gòu)式
基本信息
中文別名
化合物 T5189L 英文別名
OMadacycline (Mesylate)PTK0796 Methanesulfonate
PTK-0796 Methanesulfonate
PTK 0796 Methanesulfonate
OMadacycline Methanesulfonate
AMadacycline (Methanesulfonate)
OMADACYCLINE METHANESULFONATE
PTK 0796 METHANESULFONATE
PTK-0796 METHANESULFONATE
PTK0796 METHANESULFONATE
應(yīng)用領(lǐng)域
用途一
Omadacycline, also known as PTK 0796 and Amadacyclin, is a novel first-in-class aminomethylcycline with potent activity against important skin and pneumonia pathogens, including community-acquired methicillin-resistant Staphylococcus aureus (MRSA), β-hemolytic streptococci, penicillin-resistant Streptococcus pneumoniae, Haemophilus influenzae, and Legionella. Omadacycline is active against strains expressing the two main forms of tetracycline resistance (efflux and ribosomal protection). The primary effect of omadacycline is on bacterial protein synthesis, inhibiting protein synthesis with a potency greater than that of tetracycline. The binding site for omadacycline is similar to that for tetracycline.常見(jiàn)問(wèn)題列表
概述
Omadacycline (PTK 0796) mesylate，首創(chuàng)的具有口服活性的氨基甲基環(huán)素抗菌劑，是一種四環(huán)素類(lèi)抗生素。Omadacycline mesylate 通過(guò)與 30S 核糖體亞基結(jié)合來(lái)抑制細(xì)菌蛋白質(zhì)的合成。Omadacycline mesylate 對(duì)多種細(xì)菌表現(xiàn)出活性，包括好氧和厭氧革蘭氏陽(yáng)性細(xì)菌和革蘭氏陰性細(xì)菌，非典型病原體。Omadacycline mesylate 可用于研究急性細(xì)菌性皮膚和皮膚結(jié)構(gòu)感染，感染性肺炎和尿路感染。