一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

返回ChemicalBook首頁>CAS數(shù)據(jù)庫列表>1198769-38-8

1198769-38-8

中文名稱 化合物 T23174
英文名稱 Posaconazole (hydrate)
CAS 1198769-38-8
分子式 C37H44F2N8O5
分子量 718.81
MOL 文件 1198769-38-8.mol
1198769-38-8 結(jié)構(gòu)式 1198769-38-8 結(jié)構(gòu)式

基本信息

中文別名
泊沙康唑水合物
化合物 T23174
POSACONAZOLE水合物
英文別名
SCH-56592 HYDRATE
Posaconazole (hydrate)
所屬類別
生物化工:激動劑抑制劑

物理化學(xué)性質(zhì)

儲存條件-20°C儲存
溶解度溶于二甲基亞砜
形態(tài)粉末

常見問題列表

生物活性
Posaconazole水合物是Lanosterol-14去甲基酶抑制劑,IC50為0.25 nM。
靶點

antifungal

體外研究

Posaconazole has potent trypanocidal activity. Amiodarone acts synergistically with Posaconazole. Posaconazole also affects and disrupts Ca 2+ homeostasis in T. cruzi . Posaconazole blocks the biosynthesis of ergosterol, which is essential for parasite survival. Posaconazole has a clear, dose-dependent effect on proliferation of the epimastigote (extracellular) stages, with a minimal inhibitory concentration of 20 nM and an IC 50 of 14 nM. Against the clinically relevant intracellular amastigote form of the parasite, Posaconazole is even more potent. Posaconazole has the minimal inhibitory concentration and IC 50 values of 3 nM and 0.25 nM. Posaconazole is active against isolates of Candida and Aspergillus spp. that exhibit resistance to Fluconazole, Voriconazole, and Amphotericin B and is much more active than the other triazoles against zygomycetes.

體內(nèi)研究

Treatment of infected animals with amiodarone alone reduces parasitemia, increases survival 60 days pi (0% for untreated controls vs 40% for amiodarone-treated animals) and, when given in combination with Posaconazole, delays the development of parasitemia. Coadministration of Posaconazole and Boost Plus increases drug exposure compared to the administration of Posaconazole alone in the fasted state. Food, particularly meals high in fat content, significantly increases Posaconazole bioavailability. Systemic exposure to Posaconazole increases 4- and 2.6-fold when it is consumed with a high-fat and nonfat meal, respectively. Posaconazole and Amiodarone may constitute an effective anti-T. cruzi therapy with low side effect. At twice-daily doses of ≥ 15 mg/kg of body weight, Posaconazole prolongs the survival of the mice and reduces tissue burden.

"1198769-38-8" 相關(guān)產(chǎn)品信息
金堂县| 偏关县| 顺平县| 章丘市| 富源县| 棋牌| 陇西县| 彭州市| 昭通市| 霍州市| 泾阳县| 饶阳县| 八宿县| 泸溪县| 黎川县| 镶黄旗| 青铜峡市| 贵港市| 东乌珠穆沁旗| 同德县| 满洲里市| 盐亭县| 二连浩特市| 许昌市| 安阳县| 乌拉特后旗| 报价| 松滋市| 米泉市| 姚安县| 兴化市| 永寿县| 建阳市| 会理县| 星座| 安溪县| 安多县| 石景山区| 朝阳区| 湖南省| 红桥区|