119953-02-5
英文名稱
collagen type IV alpha1 (531-543)
CAS
119953-02-5
分子式
C74H110N18O21
分子量
1587.77
MOL 文件
119953-02-5.mol
119953-02-5 結(jié)構(gòu)式
基本信息
英文別名
collagen type IV alpha1 (531-543)L-Lysine, glycyl-L-α-glutamyl-L-phenylalanyl-L-tyrosyl-L-phenylalanyl-L-α-aspartyl-L-leucyl-L-arginyl-L-leucyl-L-lysylglycyl-L-α-aspartyl-
應(yīng)用領(lǐng)域
用途一
Collagen type IV alpha1 (531-543) is a protein that in humans is encoded by the COL4A1 gene on chromosome 13. It is ubiquitously expressed in many tissues and cell types. COL4A1 is a subunit of the type IV collagen and plays a role in angiogenesis. Mutations in the gene have been linked to diseases of the brain, muscle, kidney, eye, and cardiovascular system. The COL4A1 gene also contains one of 27 SNPs associated with increased risk of coronary artery disease. It is active in directly promoting keratinocyte adhesion.