1202073-26-4
中文名稱
3-Azetidinecarboxylic acid, 1-[[3-fluoro-4-[5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl]phenyl]Methyl]-
英文名稱
3-Azetidinecarboxylic acid, 1-[[3-fluoro-4-[5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl]phenyl]Methyl]-
CAS
1202073-26-4
分子式
C26H22FN3O2S
分子量
459.54
MOL 文件
1202073-26-4.mol
1202073-26-4 結(jié)構(gòu)式
基本信息
中文別名
化合物 T29971 英文別名
AMG 369KB74649
KB-74649
KB 74649
KCMALGDZUKTGJR-UHFFFAOYSA-N
3-Azetidinecarboxylic acid, 1-[[3-fluoro-4-[5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl]phenyl]Methyl]-
應(yīng)用領(lǐng)域
用途一
AMG-369, also known as KB74649, is a potent dual S1P1/S1P5 agonist with limited activity at S1P3 and no activity at S1P2/S1P4. Dosed orally at 0.1 mg/kg, AMG-369 is shown to reduce blood lymphocyte counts 24 h postdose and delay the onset and reduce the severity of experimental autoimmune encephalomyelitis in rat.