120447-62-3
中文名稱
(+/-)-VESAMICOL HYDROCHLORIDE
英文名稱
(+/-)-VESAMICOL HYDROCHLORIDE
CAS
120447-62-3
分子式
C17H26ClNO
分子量
295.85
MOL 文件
120447-62-3.mol
120447-62-3 結(jié)構(gòu)式
基本信息
中文別名
鹽酸扎氟普汀化合物 T22486
英文別名
AH-5183(+/-)-VESAMICOL HCL
AH-5183 HYDROCHLORIDE
(±)-VesamicolHCl (AH-5183)
rel-Vesamicol Hydrochloride
(+/-)-VESAMICOL HYDROCHLORIDE
(+/-)-VesamicolmiddotHCl(AH-5183)
(+/-)-VESAMICOL HYDROCHLORIDE (AH-5183) >98%
Ah-5183((+/-)-2-(4-phenylpiperidino) cyclohexanol
(+/-)-2-(4-PHENYLPIPERIDINO)CYCLOHEXANOL HYDROCHLORIDE
常見問題列表
生物活性
(±)-Vesamicol hydrochloride ((±)-AH5183 hydrochloride) 是一種有效的囊泡乙酰膽堿轉(zhuǎn)運 (vesicular acetylcholine transport) 抑制劑，Ki 為 2 nM。(±)-Vesamicol hydrochloride 也對 σ1 和 σ2 受體具有高親和力，Ki 值分別為 26 nM 和 34 nM。靶點
Ki: 2 nM (Vesicular acetylcholine transport), 26 nM (σ1 receptors) and 34 nM (σ2 receptors)
體外研究
The pharmacological actions of (±)-Vesamicol have been attributed to inhibition of acetylcholine transport into synaptic vesicles and the subsequent quantal release of acetylcholine.
體內(nèi)研究
(±)-Vesamicol (3 mg/kg; intraperitoneal injection; once; male Wistar rats) treatment increases the levels of cytosolic acetylcholine (ACh) in all regions of the brain, while those of vesicular ACh decreased in all regions except for the striatum.
| Animal Model: | Male Wistar rats (120-300 g) |
| Dosage: | 3 mg/kg |
| Administration: | Intraperitoneal injection; once |
| Result: | The levels of cytosolic acetylcholine (ACh) increased in all regions of the brain, while those of vesicular ACh decreased in all regions except for the striatum. |