120788-07-0
120788-07-0 結(jié)構(gòu)式
基本信息
硫陪南
Sulopenem
CP-65207-S
Sulopenem USP/EP/BP
(S)-3-[[(5R)-2-Carboxy-6β-[(R)-1-hydroxyethyl]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]tetrahydrothiophene 1-oxide
(5R,6S)-6-[(1R)-1-Hydroxyethyl]-7-oxo-3-[[(1R,3S)-tetrahydro-1-oxido-3-thienyl]thio]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(1R)-1-hydroxyethyl]-7-oxo-3-[[(1R,3S)-tetrahydro-1-oxido-3-thienyl]thio]-, (5R,6S)-
物理化學(xué)性質(zhì)
常見問題列表
硫培南是一種具有口服活性的腸胃外青霉烯類抗生素，對(duì)革蘭氏陽(yáng)性菌和革蘭氏陰性菌具有廣譜活性。它可用于尿路感染和腹腔內(nèi)感染的研究，它對(duì)銅綠假單胞菌和嗜黃單胞菌的嗜麥芽孢桿菌無(wú)效。
MIC: 0.015-0.12?μg/mL ( E. coli )
Sulopenem has the potential for uncomplicated and complicated urinary tract infections and intra-abdominal infections treatment, including multidrug-resistant (MDR) infections and infections attributable to quinolone-nonsusceptible and/or extended-spectrum β-lactamase (ESBL)-producing Gram-negative bacilli.
Sulopenem inhibits the growth of most isolates of aerobic and anaerobic Gram-positive and Gram-negative bacteria, including methicillin-susceptible
Staphylococcus aureus
,
Streptococcus pneumoniae
(penicillin-susceptible and -resistant isolates), group A and B β-hemolytic streptococci,
Listeria monocytogenes
,
Enterobacteriaceae
,
Haemophilus influenzae
, and
Moraxella catarrhalis
but excluding
P. aeruginosa
and
Stenotrophomonas maltophilia
, at a concentration of ≤1?μg/mL.
The protective effects of Sulopenem in murine experimental systemic infections are superior to those of Imipenem/Cilastatin. In murine experimental mixed infection with Escherichia coli and Bacteroides fragilis , Sulopenem has lower ED 50 . In guinea pigs experimental lung infection with Klebsiella pneumoniae , Sulopenem is more effective than CZON or Cefotiam.