121009-77-6
中文名稱
辛伐他汀EP雜質(zhì)A
英文名稱
simvastatin acid
CAS
121009-77-6
分子式
C25H40O6
分子量
436.585
MOL 文件
121009-77-6.mol
121009-77-6 結(jié)構(gòu)式
基本信息
中文別名
辛伐他汀酸化合物 T24865
英文別名
Tenivastatinsimvastatin acid
Simvastatin hydroxy acid
Simvastatin Acid D6Q: What is Simvastatin Acid D6 Q: What is the CAS Number of Simvastatin Acid D6
(βR,δR,1S)-8α-(2,2-Dimethyl-1-oxobutoxy)-1,2,6,7,8,8aβ-hexahydro-β,δ-dihydroxy-2β,6α-dimethyl-1β-naphthaleneheptanoic acid
(3R,5R)-3,5-Dihydroxy-7-[(1S)-1-(2,2-dimethylbutyryloxy)-3β,7α-dimethyl-1,2,3,7,8,8aα-hexahydronaphthalene-8α-yl]heptanoic acid
2,2-Dimethylbutyric acid (1S)-3β,7α-dimethyl-8α-[(3R,5R)-3,5-dihydroxy-6-carboxyhexyl]-1,2,3,7,8,8aα-hexahydronaphthalene-1β-yl ester
1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-, (βR,δR,1S,2S,6R,8S,8aR)-
2,2-Dimethylbutanoic acid [(1S)-1,2,3,7,8,8aα-hexahydro-3β,7α-dimethyl-8α-[(3R,5R)-3,5-dihydroxy-6-carboxyhexyl]naphthalen]-1β-yl ester
(3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid
物理化學(xué)性質(zhì)
沸點(diǎn)607.0±55.0 °C(Predicted)
密度1.13±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)4.31±0.10(Predicted)
常見問題列表
概述
辛伐他汀EP雜質(zhì)A 的水解產(chǎn)物，是一種有效的 HMG-CoA 還原酶 (HMGCR) 抑制劑。Simvastatin acid 降低吲哚酚硫酸鹽 (Indoxyl sulfate) 介導(dǎo)的活性氧 (ROS) 產(chǎn)生。Simvastatin acid 也可調(diào)節(jié)心肌細(xì)胞和轉(zhuǎn)染 OATP3A1 基因的 HEK293 細(xì)胞的 OATP3A1 表達(dá)。