1219032-18-4
中文名稱
9-酮氟前列醇異丙酯
英文名稱
9-keto Fluprostenol isopropyl ester
CAS
1219032-18-4
分子式
C26H33F3O6
分子量
498.53
MOL 文件
1219032-18-4.mol
1219032-18-4 結(jié)構(gòu)式
基本信息
中文別名
曲伏前列素雜質(zhì) 21 英文別名
9-Keto TravoprostTravoprost Impurity 21
Travoprost Impurity 35
9-KETO FLUPROSTENOL ISOPROPYL ESTER
FLUPROSTENOL PROSTAGLANDIN E2 ISOPROPYL ESTER
Travoprost Impurity 16（9-keto Fluprostenol Isopropyl Ester）
(+)-9-OXO-11ALPHA,15R-DIHYDROXY-16-(3-(TRIFLUOROMETHYL)PHENOXY)-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC-ACID, ISOPROPYL ESTER
應(yīng)用領(lǐng)域
用途一
Fluprostenol is a well-studied, potent analog of prostaglandin F2α (PGF2α) and acts primarily through the FP receptor. 9-keto Fluprostenol is an analog of PGE2 with structural modifications intended to give it a prolonged half-life and greater potency. 9-keto Fluprostenol isopropyl ester has the potential to act as an EP agonist in prodrug form. However, no studies on the pharmacology of this compound have been published to date. In addition 9-keto fluprostenol isopropyl ester is a potential metabolite of Travoprost, which is the Alcon trade name for fluprostenol isopropyl ester. In monkey cornea, this transformation was observed as a product of NADP+-dependent 15-hydroxyprostaglandin dehydrogenase when the closely related analog Latanoprost was used as a substrate. Certain F-series prostaglandins have been shown to be converted to the corresponding E-series compounds in rabbit liver and human platelet preparations.