1222088-90-5
1222088-90-5 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點657.7±55.0 °C(Predicted)
密度1.26±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)4.71±0.20(Predicted)
應(yīng)用領(lǐng)域
用途一
AM-5262 is a Potent GPR40 Full Agonist with improved rat PK profile and general selectivity profile. AM-5262 enhanced glucose stimulated insulin secretion (mouse and human islets) and improved glucose homeostasis in vivo (OGTT in HF/STZ mice) when compared to AM-1638. GPR40 (FFAR1 or FFA1) is a target of high interest being pursued to treat type II diabetes due to its unique mechanism leading to little risk of hypoglycemia.