122957-06-6
122957-06-6 結(jié)構(gòu)式
基本信息
中文別名
莫地帕泛 英文別名
Uk 80067Modipafant
ethyl (4R)-4-(2-chlorophenyl)-6-methyl-2-[4-(2-methylimidazo[4,5-c]pyridin-1-yl)phenyl]-5-(pyridin-2-ylcarbamoyl)-1,4-dihydropyridine-3-carboxylate
常見問題列表
生物活性
Modipafant (UK-80067)，UK-74505 的對映體，是一種高效、具有口服活性的選擇性的血小板活化因子 (PAF) 拮抗劑。Modipafant 展示了大約兩倍于 UK-74505 的內(nèi)在效力。體外研究
when preincubated with rabbit platelets, the potency of antagonizing PAF induced aggregation increased markedly when preincubation time with Modipafant was increased from 2 min (IC 50 =5.6 nM) to 60 min (IC 50 =0.34 nM).