1229611-73-7
中文名稱
化合物 LCRF-0004
英文名稱
LCRF-0004
CAS
1229611-73-7
分子式
C28H18F4N6O2S
分子量
578.54
MOL 文件
1229611-73-7.mol
1229611-73-7 結構式
應用領域
用途一
LCRF-0004 is a potent and selective RON receptor tyrosine kinase inhibitor. The RON receptor tyrosine kinase has been identified as an important mediator of KRAS oncogene addiction and is overexpressed in the majority of pancreatic cancers. Preclinical studies show that inhibition of RON function decreases pancreatic cancer cell migration, invasion, and survival and can sensitize pancreatic cancer cells to chemotherapy. RON receptor tyrosine kinase is a potential as a therapeutic target.