1229652-21-4
中文名稱
HA 130,自分泌運(yùn)動抑制劑
英文名稱
HA 130
CAS
1229652-21-4
分子式
C24H19BFNO5S
分子量
463.29
MOL 文件
1229652-21-4.mol
更新日期
2026/07/20 08:35:51
1229652-21-4 結(jié)構(gòu)式
基本信息
中文別名
ATX(AUTOTAXIN)抑制劑(HA130) 英文別名
HA 150HA 130
CS-1606
HA130 (HA-130)
HA130
HA-130
HA 130
HA130 (Autotaxin Inhibitor)
(Z)-3-((4-((3-(4-fluorobenzyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)methyl)phenylboronic acid
B-[3-[[4-[[3-[(4-Fluorophenyl)Methyl]-2,4-dioxo-5-thiazolidinylidene]Methyl]phenoxy]Methyl]phenyl]boronic Acid
Boronic acid, B-[3-[[4-[[3-[(4-fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]-
所屬類別
生物化工：激動劑抑制劑物理化學(xué)性質(zhì)
儲存條件-20°C儲存
溶解度DMF:10.0(Max Conc. mg/mL);21.58(Max Conc. mM)
DMSO:30.11(Max Conc. mg/mL);64.99(Max Conc. mM)
Ethanol:0.5(Max Conc. mg/mL);1.08(Max Conc. mM)
DMSO:30.11(Max Conc. mg/mL);64.99(Max Conc. mM)
Ethanol:0.5(Max Conc. mg/mL);1.08(Max Conc. mM)
形態(tài)粉末
顏色Light yellow to yellow
InChIInChI=1S/C24H19BFNO5S/c26-20-8-4-17(5-9-20)14-27-23(28)22(33-24(27)29)13-16-6-10-21(11-7-16)32-15-18-2-1-3-19(12-18)25(30)31/h1-13,30-31H,14-15H2
InChIKeyVTNKMYWFWQTEHE-UHFFFAOYSA-N
SMILESB(C1=CC=CC(COC2=CC=C(C=C3SC(=O)N(CC4=CC=C(F)C=C4)C3=O)C=C2)=C1)(O)O
常見問題列表
用途
HA 130,自分泌運(yùn)動抑制劑是一種選擇性的 autotaxin (ATX) 抑制劑，IC50 為 28 nM。
靶點(diǎn)
|
Autotaxin 28 nM (IC 50 ) |
體外研究
HA130 completely blocks the ability of ATX to promote TEM (transendothelial migration). HA130 at 0.3 μM completely ablates the activity of ATX on TK1 uropod formation.
體內(nèi)研究
HA130 slows T cell migration across lymph node HEVs. HA130 decreases the "outside HEVs/inside HEVs" ratio by 3-4-fold compared to vehicle-treated animals vehicle.
The s.c. administration of HA130 induces marked lymphocyte accumulation within the endothelial cell (EC) and sub-EC layers of HEVs in draining lymph nodes (LNs).