1240494-13-6
中文名稱
VZRIHFZJVIOJBE-UHFFFAOYSA-N
英文名稱
VZRIHFZJVIOJBE-UHFFFAOYSA-N
CAS
1240494-13-6
分子式
C19H16BFN2O3S
分子量
382.22
MOL 文件
1240494-13-6.mol
1240494-13-6 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
密度1.39±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)8.45±0.53(Predicted)
形態(tài)Solid
顏色White to off-white
應(yīng)用領(lǐng)域
用途一
SX-517 is a potent noncompetitive boronic acid CXCR1/2 antagonist. SX-517 inhibited CXCL1-induced Ca(2+) flux (IC50 = 38 nM) in human PMNs but had no effect on the Ca(2+) flux induced by C5a, fMLF, or PAF. SX-517 is the first reported boronic acid chemokine antagonist and represents a novel pharmacophore for CXCR1/2 antagonism.