一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

返回ChemicalBook首頁>CAS數(shù)據(jù)庫列表>125079-83-6

125079-83-6

中文名稱 CPD1578
英文名稱 CU-CPT-8m
CAS 125079-83-6
分子式 C14H12N4O
分子量 252.27
MOL 文件 125079-83-6.mol
更新日期 2026/07/20 17:49:24
125079-83-6 結構式 125079-83-6 結構式

基本信息

中文別名
化合物CU-CPT-8M
7-(間甲苯基)吡唑并[1,5-A]嘧啶-3-甲酰胺
英文別名
CPD1578
CU-CPT-8m
cas 125079-83-6
TLR8-specific antagonist
CU-CPT-8M
CAS 125079-83-6
TLR8 INHIBITOR
7-(m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 7-(3-methylphenyl)-
所屬類別
生物:拮抗劑

物理化學性質

密度1.35±0.1 g/cm3(Predicted)
儲存條件Sealed in dry,Room Temperature
溶解度Chloroform: 5 mg/ml; DMF: 0.2 mg/ml; DMSO: 0.2 mg/ml; Ethanol: slightly soluble
酸度系數(shù)(pKa)12.41±0.50(Predicted)
形態(tài)A crystalline solid
顏色White to off-white
InChIInChI=1S/C14H12N4O/c1-9-3-2-4-10(7-9)12-5-6-16-14-11(13(15)19)8-17-18(12)14/h2-8H,1H3,(H2,15,19)
InChIKeyHNKGGVGQAVODNJ-UHFFFAOYSA-N
SMILESC12=C(C(N)=O)C=NN1C(C1=CC=CC(C)=C1)=CC=N2

圖譜信息

CPD1578價格(試劑級)
報價日期產品編號產品名稱CAS號包裝價格
2026/07/06S4461CPD1578
CU-CPT-8m
125079-83-65mg2105.1元
2026/06/05HY-112050CU-CPT-8m125079-83-61 mg502元
2026/06/05HY-112050CPD1578
CU-CPT-8m
125079-83-65mg1000元

常見問題列表

生物活性
CU-CPT-8m 是 TLR8 的特異性拮抗劑,其 IC50 值為 67 nM。
靶點

TLR8

67 nM (IC 50 )

體外研究

CU-CPT-8m is a specific TLR8 antagonist, with an IC 50 of 67±10 nM and negligible cytotoxicity. The K d value of CU-CPT-8m is determined to be 220 nM. CU-CPT-8m only reduces the proinflammatory response in the TLR8-overexpressing cells strongly supports that CU-CPT-8m directly recognizes TLR8 in cells. It is particularly notable that TLR7 signaling is not affected at concentrations up to 75 μM. TLR7 and TLR8 are closely related and share many common ligands. Treatment of 1 μM CU-CPT-8m completely abolishes the elevation of TNF-α and IL-8 mRNA levels induced by R848. CU-CPT-8m inhibits R848-induced TNF-α production in the differentiated THP-1 monocytes cells in a dose-dependent manner with an IC 50 of 90±10 nM, which is in good agreement with its IC 50 value determined in HEK-Blue TLR8 cells.

"125079-83-6" 相關產品信息
2109805-75-4 2165340-32-7 2137975-08-5 1434635-54-7 2162962-69-6 827319-43-7
石河子市| 呼伦贝尔市| 新郑市| 子洲县| 和政县| 岑巩县| 富平县| 伽师县| 凤冈县| 灵山县| 奉化市| 丰镇市| 德令哈市| 沐川县| 岳阳县| 高安市| 安阳市| 保德县| 府谷县| 嵊泗县| 宣化县| 平南县| 崇礼县| 崇左市| 行唐县| 信宜市| 承德县| 广昌县| 新乐市| 马尔康县| 淮安市| 左贡县| 教育| 遂昌县| 鹤峰县| 临夏县| 元江| 光泽县| 汉寿县| 高台县| 霍林郭勒市|