一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

返回ChemicalBook首頁>CAS數(shù)據(jù)庫列表>125079-83-6

125079-83-6

中文名稱 CPD1578
英文名稱 CU-CPT-8m
CAS 125079-83-6
分子式 C14H12N4O
分子量 252.27
MOL 文件 125079-83-6.mol
更新日期 2026/07/20 17:49:24
125079-83-6 結(jié)構(gòu)式 125079-83-6 結(jié)構(gòu)式

基本信息

中文別名
化合物CU-CPT-8M
7-(間甲苯基)吡唑并[1,5-A]嘧啶-3-甲酰胺
英文別名
CPD1578
CU-CPT-8m
cas 125079-83-6
TLR8-specific antagonist
CU-CPT-8M
CAS 125079-83-6
TLR8 INHIBITOR
7-(m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 7-(3-methylphenyl)-
所屬類別
生物:拮抗劑

物理化學(xué)性質(zhì)

密度1.35±0.1 g/cm3(Predicted)
儲存條件Sealed in dry,Room Temperature
溶解度Chloroform: 5 mg/ml; DMF: 0.2 mg/ml; DMSO: 0.2 mg/ml; Ethanol: slightly soluble
酸度系數(shù)(pKa)12.41±0.50(Predicted)
形態(tài)A crystalline solid
顏色White to off-white
InChIInChI=1S/C14H12N4O/c1-9-3-2-4-10(7-9)12-5-6-16-14-11(13(15)19)8-17-18(12)14/h2-8H,1H3,(H2,15,19)
InChIKeyHNKGGVGQAVODNJ-UHFFFAOYSA-N
SMILESC12=C(C(N)=O)C=NN1C(C1=CC=CC(C)=C1)=CC=N2

圖譜信息

CPD1578價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2026/07/06S4461CPD1578
CU-CPT-8m
125079-83-65mg2105.1元
2026/06/05HY-112050CU-CPT-8m125079-83-61 mg502元
2026/06/05HY-112050CPD1578
CU-CPT-8m
125079-83-65mg1000元

常見問題列表

生物活性
CU-CPT-8m 是 TLR8 的特異性拮抗劑,其 IC50 值為 67 nM。
靶點

TLR8

67 nM (IC 50 )

體外研究

CU-CPT-8m is a specific TLR8 antagonist, with an IC 50 of 67±10 nM and negligible cytotoxicity. The K d value of CU-CPT-8m is determined to be 220 nM. CU-CPT-8m only reduces the proinflammatory response in the TLR8-overexpressing cells strongly supports that CU-CPT-8m directly recognizes TLR8 in cells. It is particularly notable that TLR7 signaling is not affected at concentrations up to 75 μM. TLR7 and TLR8 are closely related and share many common ligands. Treatment of 1 μM CU-CPT-8m completely abolishes the elevation of TNF-α and IL-8 mRNA levels induced by R848. CU-CPT-8m inhibits R848-induced TNF-α production in the differentiated THP-1 monocytes cells in a dose-dependent manner with an IC 50 of 90±10 nM, which is in good agreement with its IC 50 value determined in HEK-Blue TLR8 cells.

"125079-83-6" 相關(guān)產(chǎn)品信息
2109805-75-4 2165340-32-7 2137975-08-5 1434635-54-7 2162962-69-6 827319-43-7
临沂市| 军事| 武鸣县| 红桥区| 瑞金市| 上林县| 鹤庆县| 石渠县| 阳春市| 神农架林区| 上林县| 申扎县| 宜黄县| 林西县| 崇左市| 嘉兴市| 龙泉市| 柏乡县| 普格县| 金湖县| 土默特右旗| 永济市| 望城县| 曲阳县| 信丰县| 南木林县| 介休市| 来宾市| 白山市| 泾阳县| 沙河市| 靖西县| 静乐县| 洞头县| 谷城县| 泽普县| 中超| 睢宁县| 神农架林区| 河津市| 达尔|