1254733-98-6
中文名稱
SSTR5 ANTAGONIST 2 TFA
英文名稱
SSTR5 antagonist 2 TFA
CAS
1254733-98-6
分子式
C34H36F4N2O7
分子量
660.66
MOL 文件
1254733-98-6.mol
1254733-98-6 結(jié)構(gòu)式
常見問(wèn)題列表
生物活性
SSTR5 antagonist 2 TFA (compound 10) 是強(qiáng)效的、具有口服活性的生長(zhǎng)激素抑制激素(受體)亞型 5 (SSTR5) 的選擇性拮抗劑，有潛力用于 2 型糖尿病的研究。靶點(diǎn)
SSTR5.
體內(nèi)研究
SSTR5 antagonist 2 (10 mg/kg, orally) increases both total and active circulating incretin hormone GLP1 levels in mice at a dose of 10 mg/kg.
SSTR5 antagonist 2 increases pancreatic insulin secretion as well as total and active GLP1 release, and demonstrates synergistic effects in combination with DPP4 inhibitors.
| Animal Model: | Rodent diabetic model without risk of hypoglycemia. |
| Dosage: | 10 mg/kg. |
| Administration: | Orally. |
| Result: | Increased both total and active circulating incretin hormone GLP1 levels. |