125598-87-0
125598-87-0 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)1081.5±65.0 °C(Predicted)
密度1.272±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)4.20±0.10(Predicted)
應(yīng)用領(lǐng)域
用途一
A-57696 is a cholecystokinin antagonist. It is selective for cortical CCK-B receptors (IC50 = 25 nM), compared with pancreatic CCK-A receptors (IC50 = 15 microM). It is a competitive antagonist in reversing CCK8-stimulated pancreatic amylase secretion and phosphoinositide breakdown. A-57696 behaved as a partial agonist in stimulating calcium mobilization at CCK-B/gastrin receptors.