125720-84-5
中文名稱
125720-84-5
英文名稱
1-[2-(2-Propenyl)phenoxy]-3-isopropylaminoacetone (E)-oxime
CAS
125720-84-5
分子式
C15H22N2O2
分子量
262.347
MOL 文件
125720-84-5.mol
125720-84-5 結(jié)構(gòu)式
基本信息
中文別名
化合物 T10001 英文別名
CDDD-1815(E)-Alprenoxime
1-[2-(2-Propenyl)phenoxy]-3-isopropylaminoacetone (E)-oxime
2-Propanone, 1-[(1-methylethyl)amino]-3-[2-(2-propenyl)phenoxy]-, oxime, (E)- (9CI)
物理化學(xué)性質(zhì)
沸點(diǎn)398.7±37.0 °C(Predicted)
密度1.02±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)11.41±0.10(Predicted)
常見問題列表
生物活性
(E)-Alprenoxime 是 Alprenoxime 的異構(gòu)體。Alprenoxime 是一種位點(diǎn)活化的 β 阻斷劑。靶點(diǎn)
β blocker
體內(nèi)研究
The purpose of the present study is to explore the pharmacological significance of Alprenoxime peripheral /βblocking activity in a non-rodent animal model. Interspecies scaling considerations predict that the doses selected in this study (1 and 5 mg/kg) are pharmacologically comparable or greater than doses used in rodent studies (2 and 6 mg/kg). More importantly, the prolonged ocular antihypertensive effects that are shown with 1% ophthalmic solutions indicate that the i.v. dose tested in the present study is likely to be more than two orders of magnitude greater than probable therapeutic doses.