125743-80-8
中文名稱
氯雷他定雜質F
英文名稱
Loratadine EP IMpurity F
CAS
125743-80-8
分子式
C22H24ClFN2O2
分子量
402.89
MOL 文件
125743-80-8.mol
更新日期
2026/07/14 12:12:38
125743-80-8 結構式
基本信息
中文別名
氯雷他定雜質F氯雷他定雜質06
氯雷他定EP雜質F
11-氟二氫氯雷他定
氯雷他定雜質F(EP)
氯雷他定雜質16(EP雜質F)
4-(8-氯-11-氟-6,11-二氫-5H-苯并[5,6]環(huán)庚[1,2-B]吡啶-11-基)-1-哌啶羧酸,乙酯
英文別名
FluoroloratadineEthyl 4-[(11RS)-8-chloro-11-fluoro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]piperidine-1-carboxylate
Loratadine EP IMpurity F
11-Fluoro Dihydroloratadine
OVPFJWGOZPZTKG-UHFFFAOYSA-N
Ethyl 4-[(11RS)-8-Chloro-11-fluoro-
Loratadine Impurity 4/Loratadine EP Impurity F
Loratadine Impurity 6(Loratadine EP Impurity F)
Ethyl 4-((11RS)-8-chloro-11-fluoro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidi
ethyl 4-(8-chloro-11-fluoro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidine-1-carboxylate
所屬類別
分析化學：藥典標準品和雜質標準品物理化學性質
熔點149-153 °C
沸點490.3±45.0 °C(Predicted)
密度1.29±0.1 g/cm3(Predicted)
儲存條件2-8°C
溶解度Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
酸度系數(shù)(pKa)3.65±0.40(Predicted)
形態(tài)neat
InChIInChI=1S/C22H24ClFN2O2/c1-2-28-21(27)26-12-9-17(10-13-26)22(24)19-8-7-18(23)14-16(19)6-5-15-4-3-11-25-20(15)22/h3-4,7-8,11,14,17H,2,5-6,9-10,12-13H2,1H3
InChIKeyOVPFJWGOZPZTKG-UHFFFAOYSA-N
SMILESN1(C(OCC)=O)CCC(C2(F)C3=NC=CC=C3CCC3=CC(Cl)=CC=C32)CC1