125941-87-9

中文名稱 125941-87-9

英文名稱 R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride

CAS 125941-87-9

分子式 C17H18ClNOHCl

分子量 324.24

MOL 文件 125941-87-9.mol

更新日期 2024/06/12 17:31:29

125941-87-9 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息 125941-87-9價(jià)格(試劑級) 常見問題列表

基本信息

中文別名

化合物SCH 23390 HYDROCHLORIDE
(R)-8-氯-3-甲基-5-苯基-2,3,4,5-四氫-1H-苯并[D]氮雜卓-7-醇鹽酸鹽

英文別名

R(+)-SCH-23390
SCH 23390(HCI)
SCH 23390 HYDROCHLORIDE
SCH 23390 hydrochloride NEW
(+)-SCH23390 Hydrochloride, 98.0+ % (HPLC)
R(+)-SCH-23390 HYDROCHLORIDE SELECTIVE D 1 DOPAMINE
SCH23390 HYDROCHLORIDE
SCH-23390 HYDROCHLORIDE
R-(+)-SCH23390 HYDROCHLORIDE
R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
(5R)-8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrochloride
R(+)-7-CHLORO-8-HYDROXY-3-METHYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROCHLORIDE

物理化學(xué)性質(zhì)

比旋光度+27～+31°(D/20℃)(c=0.5,DMF)

儲(chǔ)存條件protect from light

溶解度在水中的溶解度>5mg/mL

形態(tài)固體

顏色白色

旋光度 (Optical Rotation)[α]/D +32.1°, c = 1 in DMF(lit.)

水溶解性water: 100mM

InChI1S/C17H18ClNO.ClH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H/t15-;/m1./s1

InChIKeyOYCAEWMSOPMASE-XFULWGLBSA-N

SMILESCl[H].CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c3ccccc3

EPA化學(xué)物質(zhì)信息(5R)-8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrochloride (125941-87-9)

安全數(shù)據(jù)

WGK Germany3

存儲(chǔ)類別13 - Non Combustible Solids

圖譜信息

125941-87-9(125941-87-9)核磁圖(¹HNMR)

125941-87-9價(jià)格(試劑級)

報(bào)價(jià)日期	產(chǎn)品編號(hào)	產(chǎn)品名稱	CAS號(hào)	包裝	價(jià)格
2026/03/03	S0476	125941-87-9 SCH-23390 hydrochloride	125941-87-9	5mg	1874.25元
2026/03/03	S0476	125941-87-9 SCH-23390 hydrochloride	125941-87-9	25mg	4709.25元
2026/03/03	S0476	SCH-23390 hydrochloride	125941-87-9	100mg	11796.8元

常見問題列表

生物活性

SCH-23390 hydrochloride (R-(+)-SCH-23390, SCH-23390)是一種高效且選擇性強(qiáng)的 dopamine D1-like receptor 的拮抗劑，對于D1和D5多巴胺受體亞型的Ki值分別為0.2 nM和0.3 nM。SCH-23390 hydrochloride 是一種有效的 h5-HT2C receptors 的激動(dòng)劑，Ki值為9.3 nM。SCH-23390 hydrochloride 可直接抑制 G protein-coupled inwardly rectifying potassium (GIRK) channels，IC50值為268 nM。

靶點(diǎn)

Target	Value
D1 dopamine receptor (Cell-free assay)	0.2 nM(Ki)
D5 dopamine receptor (Cell-free assay)	0.3 nM(Ki)
h5-HT2C receptor (Cell-free assay)	9.3 nM(Ki)
GIRK (Cell-free assay)	268 nM

體外研究

SCH-23390 (1?μM) treatment reverses the inhibitory effects of Isosibiricin on NLRP3 expression and the cleavages of caspase-1 and IL-1β in the LPS-induced BV-2 cells. SCH-23390 could reverse the Isosibiricin-mediated inhibition of the NLRP3/caspase-1 inflammasome pathway.

體內(nèi)研究

SCH-23390 can abolish generalized seizures evoked by the chemoconvulsants. SCH-23390 has also been used in studies of other neurological disorders in which the dopamine system has been implicated, such as psychosis and Parkinson's disease. Apart from the study of neurological disorders, SCH-23390 has been extensively used as a tool in the topographical determination of brain D ₁ receptors in rodents, nonhuman primates, and humans.
SCH-23390 is a very short-acting compound with an elimination half-life of around 25 min following administration of 0.3 mg/kg i.p. in the rat.
SCH-23390 augments dopamine-induced ductus constriction in CD-1 mouse vessels under newborn O ₂ conditions.