126088-92-4
126088-92-4 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
密度1.25±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)13.02±0.46(Predicted)
序列Ac-Thr-{d-Trp(For)}-{Phe(NMe,Bzl)}
應(yīng)用領(lǐng)域
用途一
FR 113680 is a novel tripeptide substance P antagonist with NK1 receptor selectivity. The inhibitory effect of FR 113680 on SP-induced guinea-pig ileum contraction is competitive and the pA2 value is 7.53. It suggest that FR 113680 interacts selectively with the NK1 neurokinin receptor.