12676-15-2
中文名稱
ANGIOTENSIN II (3-8), HUMAN
英文名稱
ANGIOTENSIN IV
CAS
12676-15-2
分子式
C40H54N8O8
分子量
774.915
MOL 文件
12676-15-2.mol
更新日期
2026/07/07 17:20:43
12676-15-2 結(jié)構(gòu)式
基本信息
中文別名
化合物ANGIOTENSIN IVANGIOTENSIN II 緊張素 II
英文別名
angiotensin III, 1-desarginine-Ang IV, Angiotensin II (3-8)
Angiotensin IV trifluoroacetate salt
(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(3H-imidazol-4-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid
物理化學(xué)性質(zhì)
儲(chǔ)存條件Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
溶解度H2O: ~1 mg/mL
形態(tài)powder
顏色white
序列Val-Tyr-Ile-His-Pro-Phe
常見(jiàn)問(wèn)題列表
生物活性
Angiotensin II (3-8), human 是一種活性稍弱的血管緊張素 AT1 受體激動(dòng)劑。靶點(diǎn)
Angiotensin AT 1 receptor
體內(nèi)研究
Human Angiotensin II (3-8) causes endothelium-dependent renal cortical vasodilatation, in anaesthetized rats. At doses up to 125 pmol/kg, human Angiotensin II (3-8) is without any cardiovascular effects, but with doses of 1.25 and 12.5 nmol/kg there are dose-dependent increases in mean arterial blood pressure and reductions in renal and mesenteric flows and vascular conductances.