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1287585-40-3

中文名稱 N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE
英文名稱 N-acetyl lysyltyrosylcysteine amide(Myeloperoxidase inhibitor KYC)
CAS 1287585-40-3
分子式 C20H31N5O5S
分子量 453.56
MOL 文件 1287585-40-3.mol
更新日期 2024/12/31 22:06:16
1287585-40-3 結(jié)構(gòu)式 1287585-40-3 結(jié)構(gòu)式

基本信息

中文別名
三肽抑制劑
英文別名
L-Cysteinamide, N2-acetyl-L-lysyl-L-tyrosyl-
N-acetyl lysyltyrosylcysteine amide(Myeloperoxidase inhibitor KYC)
所屬類別
生物化工:多肽

物理化學(xué)性質(zhì)

沸點(diǎn)902.5±65.0 °C(Predicted)
密度1.273±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C, protect from light
酸度系數(shù)(pKa)9.18±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
InChIKeyJTHKLTJLEVKKFW-ULQDDVLXSA-N
SMILESC(N)(=O)[C@H](CS)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CCCCN)NC(C)=O
N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2026/06/05HY-125039N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE
N-Acetyl lysyltyrosylcysteine amide
1287585-40-31 mg900元
2026/06/05HY-125039N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE
N-Acetyl lysyltyrosylcysteine amide
1287585-40-35 mg2250元
2026/06/05HY-125039N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE
N-Acetyl lysyltyrosylcysteine amide
1287585-40-310 mM * 1 mLin Water2475元

常見問題列表

生物活性
N-Acetyl lysyltyrosylcysteine amide 是一種有效的,可逆的,特異性且無毒的髓過氧化物酶 (MPO) 三肽抑制劑。N-Acetyl lysyltyrosylcysteine amide 在體內(nèi)可有效抑制 MPO 產(chǎn)生有毒氧化劑。N-Acetyl lysyltyrosylcysteine amide 減輕中風(fēng)后大腦的神經(jīng)元損傷,并保留腦組織和神經(jīng)功能。N-Acetyl lysyltyrosylcysteine amide 抑制MPO依賴性次氯酸 (HOCl) 的生成,蛋白質(zhì)硝化和 LDL 氧化。
體內(nèi)研究

N-Acetyl lysyltyrosylcysteine amide (KYC) significantly decreases infarct size, blood-brain barrier leakage, infiltration of myeloid cells, loss of neurons, and apoptosis in the brains of middle cerebral artery occlusion (MCAO) mice.
N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 3-7 days) significantly reduces neurological severity scores and infarct size in MCAO mice.
N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily 7 days) significantly protects BBB function and decreased neutrophil infiltration. N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily 7 days) significantly reduces microglia/macrophage activation and neuron loss in MCAO mice. N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 3-7 days) decreases apoptosis and cell injury in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide reduced MPO in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide reduces NO2Tyr and 4-HNE in MCAO mice.

Animal Model: 8-10 weeks old C57BL/6J mice (middle cerebral artery occlusion (MCAO) mode)
Dosage: 10 mg/kg
Administration: I.p.; daily for 3-7 days
Result: Significantly reduced neurological deficit and brain infarct size in mice subjected to MCAO.
"1287585-40-3" 相關(guān)產(chǎn)品信息
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