1303607-59-1
中文名稱
化合物 MI-888 FREE BASE
英文名稱
Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, 6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-N-(cis-3-hydroxy-3-methylcyclobutyl)-2-oxo-, (2'S,3R,4'S,5'R)-
CAS
1303607-59-1
分子式
C28 H32 Cl2 F N3 O3
分子量
548.48
MOL 文件
1303607-59-1.mol
1303607-59-1 結(jié)構(gòu)式
基本信息
中文別名
化合物 MI-888 FREE BASE 英文別名
Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, 6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-N-(cis-3-hydroxy-3-methylcyclobutyl)-2-oxo-, (2'S,3R,4'S,5'R)-物理化學(xué)性質(zhì)
沸點(diǎn)712.2±60.0 °C(Predicted)
密度1.38±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)12.03±0.70(Predicted)
應(yīng)用領(lǐng)域
用途一
MI-888 is a potent MDM2 inhibitor (Ki = 0.44 nM) with a superior pharmacokinetic profile and enhanced in vivo efficacy. MI-888 is capable of achieving rapid, complete, and durable tumor regression in two types of xenograft models of human cancer with oral administration and represents the most potent and efficacious MDM2 inhibitor reported to date.