130466-38-5
中文名稱
130466-38-5
英文名稱
Methanesulfonamide,N-[2-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2'-oxospiro[2H-benzofuro[2,3-a]quinolizine-2,4'-imidazolidin]-3'-yl]ethyl]-,hydrochloride (1:1)
CAS
130466-38-5
分子式
C20H27ClN4O4S
更新日期
2023/03/20 15:41:21
分子量
454.97
MOL 文件
130466-38-5.mol
130466-38-5 結(jié)構(gòu)式
基本信息
中文別名
化合物 T13285 英文別名
MK-467 hydrochlorideL-659066 hydrochloride
Vatinoxan hydrochloride
Methanesulfonamide,N-[2-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2'-oxospiro[2H-benzofuro[2,3-a]quinolizine-2,4'-imidazolidin]-3'-yl]ethyl]-,hydrochloride (1:1)
物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C儲(chǔ)存
形態(tài)Solid
顏色White to off-white
水溶解性Water : ≥ 133 mg/mL (292.33 mM)
130466-38-5價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/12/22 | HY-19057A | Vatinoxan hydrochloride | 130466-38-5 | 1 mg | 3350元 |
| 2025/12/22 | HY-19057A | 130466-38-5 Vatinoxan hydrochloride | 130466-38-5 | 10 mM * 1 mLin DMSO | 8508元 |
| 2025/02/08 | HY-19057A | 130466-38-5 Vatinoxan hydrochloride | 130466-38-5 | 10 mM * 1 mLin Water | 8508元 |
常見問題列表
生物活性
Vatinoxan hydrochloride (MK-467hydrochloride;L-659066 hydrochloride) 是一種外周 α2 腎上腺素能受體 (α2 adrenergic receptor) 拮抗劑。靶點(diǎn)
α2 adrenergic receptor
體內(nèi)研究
Vatinoxan alone increases cardiac index and tissue oxygen delivery and has no deleterious adverse effects. Vatinoxan attenuates or prevents dexmedetomidine’s systemic hemodynamic effects in a dose-dependent manner when given simultaneously i.v. but has no effect on the pulmonary outcome in conscious dogs. A 50:1 dose ratio (Vatinoxan:dexmedetomidine) induces the least alterations in cardiovascular function. Vatinoxan dose-dependently attenuates the bradycardia associated with dexmedetomidine, and shortens the sedative effect without altering its quality. Vatinoxan may be useful in attenuating reductions in heart rate in conscious catsadministered dexmedetomidine.