1309435-78-6
中文名稱
化合物 T27938
英文名稱
(S)-3-(4-((5-((2,3-DIHYDROSPIRO[INDENE-1,4-PIPERIDIN]-1-YL)METHYL)THIOPHEN-2-YL)METHOXY)PHENYL)HEX-4-YNOIC ACID
CAS
1309435-78-6
分子式
C31H33NO3S
分子量
499.66
MOL 文件
1309435-78-6.mol
1309435-78-6 結(jié)構(gòu)式
基本信息
中文別名
化合物 T27938 英文別名
(S)-3-(4-((5-((2,3-DIHYDROSPIRO[INDENE-1,4-PIPERIDIN]-1-YL)METHYL)THIOPHEN-2-YL)METHOXY)PHENYL)HEX-4-YNOIC ACID應(yīng)用領(lǐng)域
用途一
LY2922083 is a Potent and Selective GPR40 Agonist for the Treatment of Type 2 Diabetes Mellitus. LY2922083 demonstrated potent, efficacious and durable dose dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion during preclinical testing. The G protein-coupled receptor 40 (GPR40) also known as Free Fatty Acid Receptor 1 (FFAR1) is highly expressed in pancreatic, islet beta-cells and responds to endogenous fatty acids resulting in amplification of insulin secretion only in the presence of elevated glucose levels.