133161-96-3
133161-96-3 結(jié)構(gòu)式
基本信息
英文別名
PGDMTETRANOR-PGDM
TETRANOR-PROSTAGLANDIN D METABOLITE
(Z)-9α-11β-dihydroxy-15-oxo-2,3,18.19-tetranorprost-5-ene-1,20-dioic acid
Cyclopentanehexanoic acid, 2-[(2Z)-4-carboxy-2-buten-1-yl]-3,5-dihydroxy-γ-oxo-, (1R,2R,3S,5S)-
應(yīng)用領(lǐng)域
用途一
Prostaglandin D2 (PGD2) plays a pharmacological role in allergic and asthmatic anaphylaxis, normal physiological sleep and lowering of body temperature, as well as inhibits platelet aggregation and relaxes vascular smooth muscle. PGDM is a major urinary metabolite of PGD2 with a unique lower sidechain that readily undergoes reversible cyclization. It is used as a biomarker to assess endogenous production of PGD2.