1331959-78-4
1331959-78-4 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)533.7±50.0 °C(Predicted)
密度1.23±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)3.98±0.30(Predicted)
應(yīng)用領(lǐng)域
用途一
HAC-Y6 is a novel and potent microtubule inhitor. HAC-Y60 exhibited potent antitumor activity against human hepatocellular carcinoma (HCC) cells in vitro. Western blot and immunofluorescence experiments showed that HAC-Y6 depolymerized microtubules similarly to the effects of colchicine. HAC-Y6 exhibited its antitumor activity by disrupting microtubule assembly, causing cell cycle arrest and apoptosis through both extrinsic and intrinsic pathways in Hep3B cells. ( Oncol Rep. 2010 Nov;24(5):1169-78. )