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1332390-06-3

英文名稱 2-Pyridinecarbonitrile, 5-[5-[4-[(1-methyl-4-piperidinyl)oxy]phenyl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-7-yl]-3-(trifluoromethyl)-
CAS 1332390-06-3
分子式 C25H24F3N5O2S
分子量 515.55
MOL 文件 1332390-06-3.mol
1332390-06-3 結構式 1332390-06-3 結構式

基本信息

英文別名
2-Pyridinecarbonitrile, 5-[5-[4-[(1-methyl-4-piperidinyl)oxy]phenyl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-7-yl]-3-(trifluoromethyl)-

應用領域

用途一
JNJ-pan-AR, a meylated analogue of JNJ-63576253, is a novel pan-AR antagonist with potent activity against wild-type and clinically relevant AR mutations including F877L. JNJ63576253, also known as TRC253, is a potent and orally active androgen receptor antagonist. TRC253 specifically binds to both wild-type and certain mutant forms of AR, thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus.
"1332390-06-3" 相關產(chǎn)品信息
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