133575-27-6
中文名稱
ARA-F-NAD+
英文名稱
133575-27-6
CAS
133575-27-6
分子式
C21H26FN7O13P2
分子量
665.42
MOL 文件
133575-27-6.mol
133575-27-6 結(jié)構(gòu)式
常見(jiàn)問(wèn)題列表
生物活性
Ara-F-NAD+ 是 NAD+ 的 arabino 類似物，是一種有效的、緩慢結(jié)合的 CD38 NADase 抑制劑，其 Ki 為 1. 69 nM.體外研究
The leucoyte surface antigen CD38 has been shown to be an ecto-enzyme with multiple catalytic activities. It is principally a NAD + glycohydrolase that transforms NAD + into ADP-ribose and nicotinamide. CD38 is also able to produce small amounts of cyclic ADP-ribose (ADP-ribosyl cyclase activity) and to hydrolyse this cyclic metabolite into ADP-ribose (cyclic ADP-ribose hydrolase activity).