1346669-54-2
1346669-54-2 結(jié)構(gòu)式
物理化學性質(zhì)
沸點820.6±65.0 °C(Predicted)
密度1.382±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)13.99±0.10(Predicted)
應(yīng)用領(lǐng)域
用途一
G-744 is a highly potent, selective for Btk inhibitor. G-774 is metabolically stable, well tolerated, and efficacious in an animal model of arthritis. G-744 prevents cellular functions in murine B-cells such as B-cell receptor (BCR)-mediated CD86 induction with an EC50 of 64nM. G-744 also inhibited BCR-stimulated B-cell proliferation in human B-cells (EC50 = 22 nM). In human monocytes, production of the inflammatory cytokine TNFα following activation with immune complexes was abrogated by G-744 (EC50 = 33 nM). In human whole blood, G-744 demonstrated potent inhibition of BCR-stimulated CD69 expression on Bcells with an EC50 of 87 nM.