135070-05-2
中文名稱(chēng)
E 4177
英文名稱(chēng)
E 4177
CAS
135070-05-2
分子式
C24H21N3O2
分子量
383.449
MOL 文件
135070-05-2.mol
135070-05-2 結(jié)構(gòu)式
基本信息
中文別名
化合物 T27229 英文別名
E 41772-[4-[(2-cyclopropyl-7-methylimidazo[4,5-b]pyridin-3-yl)methyl]phenyl]benzoic acid
應(yīng)用領(lǐng)域
用途一
E-4177 is an angiotensin type 1 receptor antagonist potentially for the treatment of hypertension. In rat adrenal cortex and liver, E4177 competitively inhibited the specific binding of 125I-[Sar1,Ile8]Ang II, with IC50 being (5.2 +/- 1.0) x 10(-8) M for the adrenal cortex and (1.2 +/- 0.3) x 10(-7) M for the liver. These IC50 values were similar to those for losartan, which showed an IC50 of (6.0 +/- 0.9) x 10(-8) M for the adrenal cortex and (1.3 +/- 0.5) x 10(-7) M for the liver. E4177 is a potent AT1 Ang II-receptor antagonist that may be clinically useful for the treatment of cardiovascular diseases such as hypertension.