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1351592-10-3

英文名稱 EHT-6706
CAS 1351592-10-3
分子式 C21H24N2O4
分子量 368.43
MOL 文件 1351592-10-3.mol
1351592-10-3 結構式 1351592-10-3 結構式

基本信息

英文別名
EHT-6706

應用領域

用途一
EHT-6706 is a novel microtubule-disrupting agent that targets the colchicine-binding site to inhibit tubulin polymerization. At low nM concentrations, EHT 6706 exhibits highly potent antiproliferative activity on more than 60 human tumor cell lines, even those described as being drug resistant. EHT 6706 also shows strong efficacy as a vascular-disrupting agent, since it prevents endothelial cell tube formation and disrupts pre-established vessels, changes the permeability of endothelial cell monolayers and inhibits endothelial cell migration. Genome-wide transcriptomic analysis of EHT 6706 effects on human endothelial cells shows that the antiangiogenic activity elicits gene deregulations of antiangiogenic pathways. These findings indicate that EHT 6706 is a promising tubulin-binding compound with potentially broad clinical antitumor efficacy.
"1351592-10-3" 相關產品信息
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