135330-08-4
中文名稱
RP-54745
英文名稱
RP 54745
CAS
135330-08-4
分子式
C13H12ClNOS2
分子量
297.82
MOL 文件
135330-08-4.mol
更新日期
2026/05/25 13:08:20
135330-08-4 結(jié)構(gòu)式
基本信息
中文別名
化合物RP-54745 英文別名
RP 547454-chloro-5-(1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)dithiol-3-one
3H-1,2-Dithiol-3-one, 4-chloro-5-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)-
物理化學(xué)性質(zhì)
沸點411.4±55.0 °C(Predicted)
密度1.46±0.1 g/cm3(Predicted)
儲存條件Inert atmosphere,2-8°C
溶解度DMSO : 62.5 mg/mL (209.86 mM);Water : < 0.1 mg/mL (insoluble)
酸度系數(shù)(pKa)-2.57±0.40(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
RP-54745價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2026/06/05 | HY-101716 | RP-54745 RP-54745 | 135330-08-4 | 1mg | 650元 |
| 2026/06/05 | HY-101716 | RP-54745 RP-54745 | 135330-08-4 | 5mg | 1600元 |
| 2026/06/05 | HY-101716 | RP-54745 RP-54745 | 135330-08-4 | 10mM * 1mLin DMSO | 1760元 |
常見問題列表
生物活性
RP-54745 是一種潛在的治風(fēng)濕化合物，能夠抑制噬細(xì)胞刺激和的白介素-1 (interleukin-1) 的產(chǎn)生。靶點
|
IL-1
|
體外研究
RP-54745 diminishes LPS-induced interleukin-1 (IL-1) production by murine peritoneal macrophages.
體內(nèi)研究
RP-54745 (5 mg/kg) is effective at moderating oral doses in different mouse models of induced arthritis and in the MRL/lpr mice, genetically predisposed to develop an autoimmune pathology including arthritic disorders. The clinical status of the MRL mice, and several of their disturbed biochemical and immunological parameters, improved after a 3-month treatment with RP-54745.