1358575-02-6

中文名稱化合物FTBMT

英文名稱 FTBMT

CAS 1358575-02-6

分子式 C19H16F4N4O

分子量 392.35

MOL 文件 1358575-02-6.mol

更新日期 2024/06/12 17:31:29

1358575-02-6 結(jié)構(gòu)式

基本信息物理化學(xué)性質(zhì) 安全數(shù)據(jù) 圖譜信息化合物FTBMT價格(試劑級) 常見問題列表

基本信息

中文別名

化合物FTBMT

英文別名

FTBMT
FTBMT >=98% (HPLC)
inhibit,FTBMT,Inhibitor
4-(3-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-5 -methyl-1H-1,2,4-triazol-1-yl)-2-methylbenzamide
Benzamide, 4-[3-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-5-methyl-1H-1,2,4-triazol-1-yl]-2-methyl-

物理化學(xué)性質(zhì)

儲存條件-20°C儲存

溶解度DMSO:69.62(Max Conc. mg/mL);177.44(Max Conc. mM)

形態(tài)Solid

顏色Light yellow to orange

InChIKeyTYXSIXOYTBHZFA-UHFFFAOYSA-N

SMILESNC(C1=CC=C(N2C(C)=NC(CC3=CC(F)=CC(C(F)(F)F)=C3)=N2)C=C1C)=O

安全數(shù)據(jù)

WGK GermanyWGK 3

存儲類別11 - Combustible Solids

圖譜信息

化合物FTBMT(1358575-02-6)核磁圖(¹HNMR)

化合物FTBMT價格(試劑級)

報價日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價格
2026/06/05	HY-101787	化合物FTBMT FTBMT	1358575-02-6	5mg	1100元
2026/06/05	HY-101787	化合物FTBMT FTBMT	1358575-02-6	10 mM * 1 mLin DMSO	1210元
2026/06/05	HY-101787	化合物FTBMT FTBMT	1358575-02-6	10mg	1800元

常見問題列表

生物活性

FTBMT 是選擇性的 GPR52 激動劑， EC50 為 75 nM。FTBMT 有抗精神病和促進(jìn)認(rèn)知活性。

靶點

IC50: 75 nM (GPR52)

體外研究

FTBMT (0.1-10 μM) increases intracellular cAMP levels in CHO cells expressing human, mouse, or rat GPR52, with pEC ₅₀ s of 7.03, 6.85, and 6.87, respectively.

Cell Viability Assay

Cell Line:	CHO cells (expressing GPR52 receptors) cAMP assay
Concentration:	0.1-10 μM
Incubation Time:	30 minutes
Result:	FTBMT activated cAMP signaling in vitro ^[1] .

體內(nèi)研究

FTBMT (30 mg/kg, 90 minutes) exhibits antipsychotic-like activity without causing catalepsy in mice.

FTBMT (3 or 10 mg/kg, 48 hours) improves recognition and spatial working memory in rats.

FTBMT (3, 10, 30 mg/kg, 2 hours) stimulates neuronal activity in brain regions related to cognition.

Animal Model:	Male Long-Evans rats (9 weeks old)
Dosage:	10 mg/kg
Administration:	Oral, 1 hour before memory test
Result:	A 1-hour pretreatment with FTBMT (10 mg/kg, p.o.) significantly decreases the number of memory errors induced by MK-801 ^[2] .

Animal Model:	Male ICR mice (7 to 8 weeks old)
Dosage:	3–30 mg/kg
Administration:	Oral, 60 minutes before s.c. administration of MK-801
Result:	FTBMT increases phospho-DARPP32 levels in the NAc slices ^[2] .