1360628-91-6
中文名稱
化合物M3541
英文名稱
Benzonitrile, 4-[2,3-dihydro-7-methoxy-3-methyl-8-(1-methyl-1H-pyrazol-4-yl)-2-oxo-1H-imidazo[4,5-c]quinolin-1-yl]-3-fluoro-
CAS
1360628-91-6
分子式
C23H17FN6O2
分子量
428.42
MOL 文件
1360628-91-6.mol
更新日期
2024/12/03 22:59:17
1360628-91-6 結(jié)構(gòu)式
基本信息
中文別名
化合物M3541 英文別名
4-[2,3-Dihydro-7-methoxy-3-methyl-8-(1-methyl-1H-pyrazol-4-yl)-2-oxo-1H-imidazo[4,5-c]quinolin-1-yl]-3-fluorobenzonitrileBenzonitrile, 4-[2,3-dihydro-7-methoxy-3-methyl-8-(1-methyl-1H-pyrazol-4-yl)-2-oxo-1H-imidazo[4,5-c]quinolin-1-yl]-3-fluoro-
所屬類別
醫(yī)藥中間體：雜環(huán)化合物物理化學(xué)性質(zhì)
沸點(diǎn)634.8±65.0 °C(Predicted)
密度1.41±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)5.36±0.20(Predicted)
形態(tài)Solid
顏色Off-white to light yellow
InChIInChI=1S/C23H17FN6O2/c1-28-12-14(10-27-28)15-7-16-18(8-21(15)32-3)26-11-20-22(16)30(23(31)29(20)2)19-5-4-13(9-25)6-17(19)24/h4-8,10-12H,1-3H3
InChIKeyOOCGUVCGJIUQKC-UHFFFAOYSA-N
SMILESC(#N)C1=CC=C(N2C3C4C(N=CC=3N(C)C2=O)=CC(OC)=C(C2=CN(C)N=C2)C=4)C(F)=C1
應(yīng)用領(lǐng)域
用途一
M3541 is a potent, selective, orally active ATM inhibitor with potential chemo-/radio-sensitizing and antineoplastic activities. M-3541 targets and binds to ATM, thereby inhibiting the kinase activity of ATM and ATM-mediated signaling. This prevents DNA damage checkpoint activation, disrupts DNA damage repair, induces tumor cell apoptosis, and leads to cell death of ATM-overexpressing tumor cells. In addition, M 3541 sensitizes tumor cells to chemo- and radiotherapy. ATM, a serine/threonine protein kinase, is upregulated in a variety of cancer cell types; it is activated in response to DNA damage and plays a key role in DNA-strand repair.