1362911-19-0
1362911-19-0 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
密度1.32±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度可溶于DMSO
酸度系數(shù)(pKa)7.05±0.46(Predicted)
形態(tài)Solid
顏色White to off-white
SMILESO=C(CC1=CC=CC=C1)OCOC(/N=C(NC(OCOC(CC2=CC=CC=C2)=O)=O)\NCCC[C@H](NS(C3=CC=C(C=C3)C)(=O)=O)C(OC)=O)=O
應(yīng)用領(lǐng)域
用途一
ProTAME is an inhibitor of both APC/CFzr and APC/CCdc20. Combinations of proTAME with topoisomerase inhibitors, etoposide and doxorubicin, significantly increase cell death in Multiple Myeloma (MM) cell lines and primary cells, particularly if TOPIIα levels are first increased through pre-treatment with ProTAME.常見(jiàn)問(wèn)題列表
概述
proTAME 是 TAME 的一種細(xì)胞滲透性前體形式，是一種后期促進(jìn)復(fù)合物/環(huán)體 (APC/C) 抑制劑。proTAME 導(dǎo)致細(xì)胞周期停滯在中期。