1366233-41-1
中文名稱(chēng)
GSK2332255B
英文名稱(chēng)
GSK255B)
CAS
1366233-41-1
分子式
C18H19ClFN3O3S
分子量
411.88
MOL 文件
1366233-41-1.mol
1366233-41-1 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)542.7±60.0 °C(Predicted)
密度1.417±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)0.46±0.10(Predicted)
應(yīng)用領(lǐng)域
用途一
GSK 2332255B is a potent, and selective inhibitor of TRPC3/6 channels with IC50 of 3 nM/21 nM, respectively. It dispalys >100-fold selectivity over other calcium-permeable channels. It has 100-fold greater potency for TRPC3 compared with Pyr3. GSK 2332255B (dose-dependent) blocks cell hypertrophy signaling triggered by angiotensin II or endothelin-1 in HEK293T cells as well as in neonatal and adult cardiac myocytes.