1366234-01-6
中文名稱
GSK 2833503A
英文名稱
GSK503A)
CAS
1366234-01-6
分子式
C18H21ClFN3OS
分子量
381.9
MOL 文件
1366234-01-6.mol
1366234-01-6 結構式
物理化學性質
沸點512.1±60.0 °C(Predicted)
密度1.291±0.06 g/cm3(Predicted)
溶解度Soluble to 100 mM in DMSO and to 20 mM in ethanol
酸度系數(shù)(pKa)2.52±0.10(Predicted)
應用領域
用途一
GSK 2833503A is a potent, and selective inhibitor of TRPC3/6 channels with IC50 of 4 nM/5 nM, respectively. It dispalys >100-fold selectivity over other calcium-permeable channels. It has 100-fold greater potency for TRPC3 compared with Pyr3. GSK 2833503A (dose-dependent) blocks cell hypertrophy signaling triggered by angiotensin II or endothelin-1 in HEK293T cells as well as in neonatal and adult cardiac myocytes.