1370241-45-4
1370241-45-4 結(jié)構(gòu)式
基本信息
中文別名
化合物 T12743 英文別名
RO-71H-Pyrido[2,1-f][1,2,4]triazine-4,6-dione, 1-[(11S)-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-2,3-dihydro-5-hydroxy-3-[(1R)-2,2,2-trifluoro-1-methylethyl]-
物理化學(xué)性質(zhì)
沸點594.1±60.0 °C(Predicted)
密度1.54±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)4.50±1.00(Predicted)
常見問題列表
生物活性
RO-7 是甲型和乙型流感病毒的二代聚合酶 PA 亞基內(nèi)切核酸酶抑制劑。體外研究
RO-7 is a compound that potently inhibits influenza virus replication and belongs to a new class of drugs in late-stage clinical trials for treatment of influenza virus infection. RO-7 displays broad-spectrum anti-influenza activity in vitro and protects mice from lethal challenge with both influenza A and B viruses.
體內(nèi)研究
RO-7 protects mice from lethal challenge with both influenza A and B viruses.