137028-97-8
中文名稱
化合物 T25573
英文名稱
ketomethylenebestatin
CAS
137028-97-8
分子式
C17H25NO4
分子量
307.39
MOL 文件
137028-97-8.mol
137028-97-8 結(jié)構(gòu)式
基本信息
中文別名
化合物 T25573 英文別名
ketomethylenebestatin(2R,5S,6R)-6-amino-5-hydroxy-2-(2-methylpropyl)-4-oxo-7-phenylheptanoic acid
物理化學(xué)性質(zhì)
沸點529.6±50.0 °C(Predicted)
密度1.158±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)4.51±0.23(Predicted)
應(yīng)用領(lǐng)域
用途一
Ketomethylenebestatin is a carba-analogue of the aminopeptidase (AP) inhibitor bestatin. This synthesis was carried out by a malonic ester alkylation with the suitably protected halomethyl ketone of (2S,3R)-AHPBA*), followed by a second alkylation with isobutyl bromide of the resulting 4-ketodiester, and subsequent decarboxylation and deprotection. Ketomethylenebestatin is 10 fold less effective as inhibitor of aminopeptidases than bestatin.