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1370554-01-0

中文名稱 Cilliobrevin D
英文名稱 Cilliobrevin D
CAS 1370554-01-0
分子式 C17H8Cl3N3O2
分子量 392.62
MOL 文件 1370554-01-0.mol
更新日期 2026/05/22 08:53:49
1370554-01-0 結構式 1370554-01-0 結構式

基本信息

中文別名
化合物CILIOBREVIN D
英文別名
Cilliobrevin D
Cytoplasmic Dynein Inhibitor, Ciliobrevin D
Benzenepropanenitrile, 2,4-dichloro-α-(7-chloro-3,4-dihydro-4-oxo-2(1H)-quinazolinylidene)-β-oxo-
所屬類別
有機原料:腈類化合物

物理化學性質

沸點591.8±50.0 °C(Predicted)
密度1.537±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO: 5 mg/mL (12.73 mM; ultrasonic and warming and heat to 80°C)
酸度系數(pKa)5.99±0.20(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
InChIInChI=1S/C17H8Cl3N3O2/c18-8-1-3-10(13(20)5-8)15(24)12(7-21)16-22-14-6-9(19)2-4-11(14)17(25)23-16/h1-6,22H,(H,23,25)
InChIKeyJKKSCGHDRHRWOQ-UHFFFAOYSA-N
SMILESC(=C1NC(=O)C2=CC=C(Cl)C=C2N1)(C#N)C(C1C=CC(Cl)=CC=1Cl)=O

安全數據

WGK GermanyWGK 3
存儲類別11 - Combustible Solids
Cilliobrevin D價格(試劑級)
報價日期產品編號產品名稱CAS號包裝價格
2026/03/03S9743Cilliobrevin D
Ciliobrevin D
1370554-01-05mg1613.93元
2026/03/03S9743Cilliobrevin D
Ciliobrevin D
1370554-01-025mg4832.94元
2026/03/03S9743Ciliobrevin D1370554-01-0100mg12096.9元

常見問題列表

生物活性
Ciliobrevin D (compound 5) 是一種具有細胞滲透性、可逆性和特異性的 AAA+ (ATPases associated with diverse cellular activities) ATPase 運動肌 cytoplasmic dynein 的拮抗劑。Ciliobrevin D 可干擾初級纖毛的形成并阻止 Hedgehog (Hh) 信號傳導。
靶點
TargetValue
cytoplasmic dynein
()
Hedgehog
()
體外研究

Cells treated with Ciliobrevin D exhibits abnormal (unfocused, multipolar, or collapsed) spindles with disrupted γ-tubulin localization in NIH-3T3 cells. Similar Ciliobrevin-induced spindle defects are observed in HeLa cells, although to a lesser extent. Ciliobrevin D addition also reversibly disrupts the pre-formed spindles of metaphase-arrested cells and reduces overall microtubule levels.
. Ciliobrevin D reversibly inhibits melanosome aggregation, but the non-cilia-disrupting derivative had no discernible effect at comparable doses. Ciliobrevin D similarly abrogates the movement of peroxisomes in Drosophila S2 cells.

體內研究

Knockdown of Dync1h1 or inactivation of dynein 1 by Ciliobrevin D in the testis in vivo perturbs spermatogenesis. Knockdown of Dync1h1 or the use of Ciliobrevin D to inactivate dynein 1 in the testis in vivo perturbs MT organization through changes in the spatial expression of EB1, perturbs F-actin organization, and perturbs distribution of adhesion protein complexes at the BTB, leading to a loss of BTB integrity. F-actin disorganization in the seminiferous epithelium following Dync1h1 knockdown or dynein 1 inactivation by Ciliobrevin D is mediated by changes in the spatiotemporal expression of actin regulatory proteins Arp3 and Eps8.

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