一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

返回ChemicalBook首頁(yè)>CAS數(shù)據(jù)庫(kù)列表>1370554-01-0

1370554-01-0

中文名稱 Cilliobrevin D
英文名稱 Cilliobrevin D
CAS 1370554-01-0
分子式 C17H8Cl3N3O2
分子量 392.62
MOL 文件 1370554-01-0.mol
更新日期 2026/07/15 12:24:50
1370554-01-0 結(jié)構(gòu)式 1370554-01-0 結(jié)構(gòu)式

基本信息

中文別名
化合物CILIOBREVIN D
英文別名
Cilliobrevin D
Cytoplasmic Dynein Inhibitor, Ciliobrevin D
Benzenepropanenitrile, 2,4-dichloro-α-(7-chloro-3,4-dihydro-4-oxo-2(1H)-quinazolinylidene)-β-oxo-
所屬類別
有機(jī)原料:腈類化合物

物理化學(xué)性質(zhì)

沸點(diǎn)591.8±50.0 °C(Predicted)
密度1.537±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 5 mg/mL (12.73 mM; ultrasonic and warming and heat to 80°C)
酸度系數(shù)(pKa)5.99±0.20(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
InChIInChI=1S/C17H8Cl3N3O2/c18-8-1-3-10(13(20)5-8)15(24)12(7-21)16-22-14-6-9(19)2-4-11(14)17(25)23-16/h1-6,22H,(H,23,25)
InChIKeyJKKSCGHDRHRWOQ-UHFFFAOYSA-N
SMILESC(=C1NC(=O)C2=CC=C(Cl)C=C2N1)(C#N)C(C1C=CC(Cl)=CC=1Cl)=O

安全數(shù)據(jù)

WGK GermanyWGK 3
存儲(chǔ)類別11 - Combustible Solids
Cilliobrevin D價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2026/07/06S9743Cilliobrevin D
Ciliobrevin D
1370554-01-05mg1613.93元
2026/07/06S9743Cilliobrevin D
Ciliobrevin D
1370554-01-025mg4832.94元
2026/07/06S9743Ciliobrevin D1370554-01-0100mg12096.9元

常見(jiàn)問(wèn)題列表

生物活性
Ciliobrevin D (compound 5) 是一種具有細(xì)胞滲透性、可逆性和特異性的 AAA+ (ATPases associated with diverse cellular activities) ATPase 運(yùn)動(dòng)肌 cytoplasmic dynein 的拮抗劑。Ciliobrevin D 可干擾初級(jí)纖毛的形成并阻止 Hedgehog (Hh) 信號(hào)傳導(dǎo)。
靶點(diǎn)
TargetValue
cytoplasmic dynein
()
Hedgehog
()
體外研究

Cells treated with Ciliobrevin D exhibits abnormal (unfocused, multipolar, or collapsed) spindles with disrupted γ-tubulin localization in NIH-3T3 cells. Similar Ciliobrevin-induced spindle defects are observed in HeLa cells, although to a lesser extent. Ciliobrevin D addition also reversibly disrupts the pre-formed spindles of metaphase-arrested cells and reduces overall microtubule levels.
. Ciliobrevin D reversibly inhibits melanosome aggregation, but the non-cilia-disrupting derivative had no discernible effect at comparable doses. Ciliobrevin D similarly abrogates the movement of peroxisomes in Drosophila S2 cells.

體內(nèi)研究

Knockdown of Dync1h1 or inactivation of dynein 1 by Ciliobrevin D in the testis in vivo perturbs spermatogenesis. Knockdown of Dync1h1 or the use of Ciliobrevin D to inactivate dynein 1 in the testis in vivo perturbs MT organization through changes in the spatial expression of EB1, perturbs F-actin organization, and perturbs distribution of adhesion protein complexes at the BTB, leading to a loss of BTB integrity. F-actin disorganization in the seminiferous epithelium following Dync1h1 knockdown or dynein 1 inactivation by Ciliobrevin D is mediated by changes in the spatiotemporal expression of actin regulatory proteins Arp3 and Eps8.

"1370554-01-0" 相關(guān)產(chǎn)品信息
97-18-7 958-09-8 556-67-2 207121-53-7 1370554-01-0 302803-72-1
浦江县| 永和县| 奇台县| 西藏| 抚顺县| 芒康县| 山东省| 开远市| 东乡县| 靖远县| 蓝山县| 板桥市| 临桂县| 浪卡子县| 泗洪县| 库伦旗| 土默特左旗| 图木舒克市| 鹤庆县| 读书| 孟连| 大化| 新晃| 荥经县| 图们市| 乐东| 清新县| 红河县| 宝丰县| 睢宁县| 大理市| 嘉兴市| 屏东市| 麻栗坡县| 察哈| 井研县| 凌源市| 惠水县| 手游| 谢通门县| 上虞市|