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137089-36-2

中文名稱 137089-36-2
英文名稱 2-(2-decenoylamino)ethyl-2-(cyclohexylethyl)sulfide
CAS 137089-36-2
分子式 C20H37NOS
分子量 339.58
MOL 文件 137089-36-2.mol
137089-36-2 結(jié)構(gòu)式 137089-36-2 結(jié)構(gòu)式

基本信息

英文別名
2-(2-decenoylamino)ethyl-2-(cyclohexylethyl)sulfide
2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide
2-Decenamide, N-[2-[(2-cyclohexylethyl)thio]ethyl]-, (E)- (9CI)

物理化學(xué)性質(zhì)

沸點(diǎn)503.3±42.0 °C(Predicted)
密度0.954±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)14.50±0.46(Predicted)

常見問題列表

生物活性
2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide 是一種由壓力誘發(fā)的潰瘍和低毒性抑制劑,可以在壓力引起的潰瘍大鼠中,維持磷脂酶 A2 (phospholipase A2) 和 前列腺素 E2 (prostaglandin E2) 的含量水平。
靶點(diǎn)

PGE 2

PGI 2

PLA 2

體內(nèi)研究

2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide (compd.III-1α, 100 mg/kg, p.o.) maintains the relative content of Fr.I hexose, lipid peroxide and phospholipase A2 (PLA2) in normal level in ulcerated rats induced by water immersed restrained stress via dosing twice a day for 3 day (b.i.d. for 3 d). 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide (100 mg/kg, p.o.) reduces the hexosamine content equally with the control group 4 h after the stress loading, and then markedly increases 7 h after stress loading. 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide (25 mg/kg, p.o.) blocks the reduction of prostaglandin E2 (PGE2) and PGI2 in early phase and accelerates the increase of PGE2 and PGI2 in the late phase of the stress. 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide (25 mg/kg, p.o.) also significantly accelerates the cell proliferation in fundic glands in gastric mucosa of mice.

"137089-36-2" 相關(guān)產(chǎn)品信息
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