137530-61-1
英文名稱
L-N-(N-hydroxy-2-isobutylsuccinamoyl)seryl-L-valine
CAS
137530-61-1
分子式
C16H29N3O7
分子量
375.42
MOL 文件
137530-61-1.mol
137530-61-1 結(jié)構(gòu)式
應(yīng)用領(lǐng)域
用途一
BE-16627B is a novel metalloproteinase (MP) inhibitor isolated from Streptomyces sp. BE16627B selectively inhibited MPs such as human stromelysin and 92 kD gelatinase. After the cells were cultured with BE16627B for 5 days, BE16627B inhibited MP activity in the primary culture supernatants from synovial cells in a dose-dependent fashion without showing apparent cytotoxicity or affecting the production and secretion of MPs. Its IC50 for active collagenolysis before activation by trypsin was 25 microM.