1383846-83-0
中文名稱
2(1H)-Pyridinone, 5-[(1R)-3-aMino-4-fluoro-1-[3-[5-(1-propyn-1-yl)-3-pyridinyl]phenyl]-1H-isoindol-1-yl]-1-ethyl-3-Methyl-
英文名稱
2(1H)-Pyridinone, 5-[(1R)-3-aMino-4-fluoro-1-[3-[5-(1-propyn-1-yl)-3-pyridinyl]phenyl]-1H-isoindol-1-yl]-1-ethyl-3-Methyl-
CAS
1383846-83-0
分子式
C30H25FN4O
分子量
476.54
MOL 文件
1383846-83-0.mol
1383846-83-0 結(jié)構(gòu)式
基本信息
中文別名
化合物 T26705 英文別名
AZ-4217
(AZ4217)5-[(1R)-3-amino-4-fluoro-1-[3-(5-prop-1-ynylpyridin-3-yl)phenyl]isoindol-1-yl]-1-ethyl-3-methylpyridin-2-one
2(1H)-Pyridinone, 5-[(1R)-3-aMino-4-fluoro-1-[3-[5-(1-propyn-1-yl)-3-pyridinyl]phenyl]-1H-isoindol-1-yl]-1-ethyl-3-Methyl-
物理化學(xué)性質(zhì)
沸點732.5±70.0 °C(Predicted)
密度1.21±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)3.72±0.40(Predicted)
應(yīng)用領(lǐng)域
用途一
AZ-4217 is a high potency BACE inhibitor displaying acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice. AZ-4217 has IC50 160 pM in human SH-SY5Y cells with an excellent in vivo efficacy. AZ-4217 may have potential for treatment of AD. BACE1 inhibition thus addresses a key mechanism in AD and its potential as a therapeutic target is currently being addressed in clinical studies.