138483-63-3
138483-63-3 結(jié)構(gòu)式
基本信息
中文別名
化合物 T15683 英文別名
L 689502Carbamic acid, N-[(1S,2S,4R)-5-[[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]amino]-2-hydroxy-4-[[4-[2-(4-morpholinyl)ethoxy]phenyl]methyl]-5-oxo-1-(phenylmethyl)pentyl]-, 1,1-dimethylethyl ester
物理化學(xué)性質(zhì)
沸點886.9±65.0 °C(Predicted)
密度1.24±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)12.08±0.46(Predicted)
常見問題列表
生物活性
L-689502 是一個有效的 HIV-1 蛋白酶 (HIV-l protease) 抑制劑，其 IC50 值為 1 nM。靶點
IC50: 1 nM (HIV-l protease)
體外研究
Both L694746 and L-689502 inhibit HIV-l ptotease activity in a concentration-dependent manner. Pepstatin is much less potent than either compound exhibiting an IC 50 of 2 μM. L694746 is as potent as L-689502 in inhibiting the HIV-l protease despite being structurally different from L-689502.