138661-02-6
138661-02-6 結(jié)構(gòu)式
基本信息
中文別名
噴曲肽 英文別名
DTPA-SMSPentreotide
Pentetreotide
DTPA-octreotide
Unii-G083B71p98
[DTPA-D-Phe1]octreotide
Pentreotide trifluoroacetate
CA index name: L-Cysteinamide, N-[2-[[2-bis(carboxymethyl)amino]-ethyl](carboxymethyl)amino]ethyl]-N-(carboxymethyl)glycyl-
N-[2-[[2-[Bis(carboxymethyl)amino]ethyl](carboxymethyl)amino]ethyl]-N-(carboxymethyl)-Gly-D-Phe-L-Cys(1)-L-Phe-D-Trp-L-Lys-L-Thr-L-Cys(1)-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-NH2
N-(2-((2-(Bis(carboxymethyl)amino)ethyl)(carboxymethyl)amino)ethyl)-N-(carboxymethyl)glycyl-D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (3-8)-disulfide
常見問題列表
生物活性
Pentetreotide 是 Octreotide 的 DTPA 共軛物。Pentetreotide 是一種銦標(biāo)記的生長(zhǎng)抑素類似物，可用于核醫(yī)學(xué)成像。Pentetreotide 與生長(zhǎng)抑素受體閃爍顯影可有效觀察神經(jīng)內(nèi)分泌腫瘤及其轉(zhuǎn)移。體外研究
Neuroendocrine tumors have an increased number of somatostatin receptors, as compared to normal tissues. At present time, there are five known subtypes. Somatostatin receptor scintigraphy with 111 In-Pentetreotide binds to two of these subtypes and is effective in visualizing neuroendocrine tumors, and its metastasis with an overall diagnostic sensitivity of 70% to 90%. It is considerably more sensitive than conventional anatomic imaging. Its usage in neuroendocrine tumors not only includes assessment of disease extent, but also in identified primary lesion, assesses treatment response, and selection for radionuclide therapy.