139067-52-0
139067-52-0 結(jié)構(gòu)式
基本信息
中文別名
化合物 T28331 英文別名
Cam1189Cam 1189
Cam-1189
PD 136450
(E)-4-[[(1R)-2-[[(2R)-2-(2-adamantyloxycarbonylamino)-3-(1H-indol-3-yl)-2-methylpropanoyl]amino]-1-phenylethyl]amino]-4-oxobut-2-enoic acid
物理化學(xué)性質(zhì)
沸點(diǎn)950.4±65.0 °C(Predicted)
密度1.33±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)3.49±0.10(Predicted)
應(yīng)用領(lǐng)域
用途一
Cholecystokinin type B receptor antagonist PD-136,450 is a partial secretory agonist in the stomach and a full agonist in the pancreas of the rat. Gastrin (cholecystokinin type B (CCK-B)) receptor antagonists may help to elucidate the physiological role of gastrin, have therapeutic potential as acid antisecretory drugs, and may be of use as adjuvant therapy for gastrin sensitive tumours. The agonist effect of PD-136,450 is mediated via interaction with the gastrin (CCK-B) receptor in the stomach and the CCK-A receptor in the pancreas.