139958-16-0
中文名稱
化合物 T28009
英文名稱
Pyridine, 3-methoxy-2,6-dimethyl-4-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methoxy]-
CAS
139958-16-0
分子式
C22H21N5O2
分子量
387.43
MOL 文件
139958-16-0.mol
139958-16-0 結(jié)構(gòu)式
基本信息
中文別名
化合物 T28009 英文別名
ME3221ME-3221
ME 3221
Pyridine, 3-methoxy-2,6-dimethyl-4-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methoxy]-
物理化學(xué)性質(zhì)
沸點603.1±65.0 °C(Predicted)
密度1.239±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)4.15±0.10(Predicted)
應(yīng)用領(lǐng)域
用途一
ME-3221 is an angiotensin type 1 receptor antagonist potentially for the treatment of hypertension. ME3221 prevents hypertensive complications in aged stroke-prone spontaneously hypertensive rats. n rats and marmosets, ME3221 antagonized angiotensin II-induced pressor responses, but did not affect bradykinin-induced depressor responses. ME3221 lowered the blood pressure in renal hypertensive rats and spontaneously hypertensive rats (SHR), and its ED25 value was 3 times that of losartan.