1414248-06-8
1414248-06-8 結(jié)構(gòu)式
基本信息
英文別名
SR 1903[1,1'-Biphenyl]-4-methanol, 2'-methyl-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-α,α-bis(trifluoromethyl)-
物理化學(xué)性質(zhì)
沸點(diǎn)559.0±50.0 °C(Predicted)
密度1.307±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml
酸度系數(shù)(pKa)9.23±0.15(Predicted)
形態(tài)結(jié)晶固體
應(yīng)用領(lǐng)域
用途一
SR-1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR). It is an inverse agonist of RORγ and an agonist of LXR. It also binds to peroxisome proliferator-activated receptor γ (PPAR) but does not activate it. SR-1903 inhibits LPS-induced expression of triggering receptor expressed on myeloid cells 1 (TREM-1). It also inhibits LPS-induced expression of the LXR target genes IL-6 and IL-33 and increases expression of ABCG1, FASN, and SCD-1. SR-1903 reduces the severity of collagen-induced arthritis. It reduces blood glucose levels in a glucose tolerance test, serum levels of total cholesterol and LDL, body weight, and fat mass in a mouse model of high-fat diet-induced obesity.