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1422826-80-9

英文名稱 LOR-253)
CAS 1422826-80-9
分子式 C22H14FN5
分子量 367.38
MOL 文件 1422826-80-9.mol
1422826-80-9 結(jié)構(gòu)式 1422826-80-9 結(jié)構(gòu)式

基本信息

英文別名
APTO-253 (APTO253
1H-Imidazo[4,5-f][1,10]phenanthroline, 2-(6-fluoro-2-methyl-1H-indol-3-yl)-

應用領域

用途一
APTO-253 isomer is an isomer of APTO-253 with the Fluoro-atom in 6-position. APTO-253 also known as LOR-253, LT-253, is a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1) with potential antitumor activity. MTF-1 inhibitor LOR-253 inhibits MTF-1 activity and thereby induces the expression of MTF-1 dependent tumor suppressor factor Kruppel like factor 4 (KLF4). This subsequently leads to the downregulation of cyclin D1, blocking cell cycle progression and proliferation. This agent also causes decreased expression of genes involved in tumor hypoxia and angiogenesis.
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